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Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis.

Johanna OechteringSabine SchaedelinPascal BenkertStefanie MüllerLutz AchtnichtsJochen VehoffGiulio DisantoOliver FindlingBettina Fischer-BarnicolAnnette OrlethAndrew ChanCaroline PotMuhamed BarakovicReza RahmanzadehRiccardo GalbuseraIngmar HeijnenPatrice H LaliveJens WuerfelSuvitha SubramaniamStefanie AeschbacherDavid ConenYvonne NaegelinAleksandra MaceskiStephanie MeierKlaus BergerHeinz WiendlTherese LinckeJohanna LiebÖzgür YaldizliTim SinneckerTobias DerfussAxel RegeniterChiara ZeccaClaudio GobbiLudwig KapposCristina GranzieraDavid LeppertJens Kuhlenull null
Published in: Annals of neurology (2021)
This large study supports the value of intrathecal IgM synthesis as an independent biomarker of disease activity and severity in relapsing MS. ANN NEUROL 2021;90:477-489.
Keyphrases
  • disease activity
  • multiple sclerosis
  • systemic lupus erythematosus
  • rheumatoid arthritis
  • rheumatoid arthritis patients
  • ankylosing spondylitis
  • juvenile idiopathic arthritis
  • mass spectrometry
  • white matter
  • ms ms