Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis.

Johanna OechteringSabine SchaedelinPascal BenkertStefanie MüllerLutz AchtnichtsJochen VehoffGiulio DisantoOliver FindlingBettina Fischer-BarnicolAnnette OrlethAndrew ChanCaroline PotMuhamed BarakovicReza RahmanzadehRiccardo GalbuseraIngmar HeijnenPatrice H LaliveJens WuerfelSuvitha SubramaniamStefanie AeschbacherDavid ConenYvonne NaegelinAleksandra MaceskiStephanie MeierKlaus BergerHeinz WiendlTherese LinckeJohanna LiebÖzgür YaldizliTim SinneckerTobias DerfussAxel RegeniterChiara ZeccaClaudio GobbiLudwig KapposCristina GranzieraDavid LeppertJens Kuhlenull null

Published in: Annals of neurology (2021)

This large study supports the value of intrathecal IgM synthesis as an independent biomarker of disease activity and severity in relapsing MS. ANN NEUROL 2021;90:477-489.

Keyphrases

disease activity
multiple sclerosis
systemic lupus erythematosus
rheumatoid arthritis
rheumatoid arthritis patients
ankylosing spondylitis
juvenile idiopathic arthritis
mass spectrometry
white matter
ms ms