Performance of Cervical Screening a Decade Following HPV Vaccination: The Costa Rica Vaccine Trial.
Shang-Ying HuAimée R KreimerCarolina PorrasDiego GuillénMario AlfaroTeresa M DarraghMark H StolerLuis F VillegasRebecca OcampoAna Cecilia RodriguezMark SchiffmanSabrina H TsangDouglas R LowyJohn T SchillerJohn SchusslerWim QuintMitchell H GailJoshua N SampsonAllan HildesheimRolando Herreronull nullPublished in: Journal of the National Cancer Institute (2022)
Among women approaching screening ages, vaccinated as young adults, and with a history of intensive screening, the expected reduction in the positive predictive value of HPV testing, associated with dropping prevalence of HPV-associated lesions, was not observed. This is likely due to the presence of high-grade lesions associated with nonvaccine HPV types, which may be less likely to progress to cancer.