Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies.

Subhankar P MandalAakriti GargP PrabithaAshish D WadhwaniLaxmi AdhikaryB R Prashantha Kumar

Published in: Chemistry Central journal (2018)

The results of pharmacophore, molecular docking study and in vitro evaluation of synthesized compounds were found to be in good correlation. Specifically, CPD03, 07, 08, 18, 19, 21 and 24 are the candidate glitazones exhibited significant glucose uptake activity. 3D-QSAR model revealed the scope for possible further modifications as part of optimisation to find potent anti-diabetic agents.

Keyphrases

molecular docking
molecular dynamics simulations
blood glucose
type diabetes
insulin resistance
molecular dynamics
single cell
fatty acid
single molecule
case control
weight loss