Deep Learning Based Micro-RNA Analysis of Lipopolysaccharide Exposed Periodontal Ligament Stem Cells Exosomes Reveal Apoptotic and Inflammasome Derived Pathway Activation.
Pradeep Kumar YadalamRaghavendra Vamsi AnegundiSivasankari ThilagarDeepavalli ArumuganainarDeepti ShrivastavaArtak HeboyanPublished in: Biomedical engineering and computational biology (2024)
The current study utilizes deep learning analysis of microRNA expression data to identify novel biomarkers associated with inflammasome activation and anti-apoptotic pathways. These findings hold promise for guiding the development of novel therapeutic strategies for periodontal disease. However, future studies are warranted to validate these biomarkers using independent datasets and experimental methods.
Keyphrases
- deep learning
- stem cells
- cell death
- big data
- artificial intelligence
- poor prognosis
- convolutional neural network
- mesenchymal stem cells
- machine learning
- anti inflammatory
- electronic health record
- toll like receptor
- genome wide
- binding protein
- single cell
- rna seq
- gene expression
- cell therapy
- long non coding rna
- case control
- data analysis