Impact of COVID-19 Severity on Long-term Events in US Veterans using the Veterans Affairs Severity Index for COVID-19 (VASIC).
Ashley GallowayYojin ParkVidisha TanukondaYuk-Lam HoXuan-Mai T NguyenMonika MaripuriAndrew T DeyHanna GerlovinDaniel PosnerKristine E LynchTianxi CaiShiuh-Wen LuohStacey WhitbourneDavid R GagnonSumitra MuralidharPhillip S TsaoJuan P CasasJ Michael GazianoPeter Wf WilsonAdriana M HungKelly ChoPublished in: The Journal of infectious diseases (2022)
In this retrospective cohort study of 94,595 SARS-CoV-2 positive cases, we developed and validated an algorithm to assess the association between COVID-19 severity and long-term complications (stroke, myocardial infarction, pulmonary embolism/deep vein thrombosis, heart failure, and mortality). COVID-19 severity was associated with a greater risk of experiencing a long-term complication days 31-120 post-infection. Most incident events occurred days 31-60 post-infection and diminished after day 91, except heart failure for severe patients and death for moderate patients, which peaked days 91-120. Understanding the differential impact of COVID-19 severity on long-term events provide insight into possible intervention modalities and critical prevention strategies.
Keyphrases
- sars cov
- coronavirus disease
- heart failure
- pulmonary embolism
- end stage renal disease
- respiratory syndrome coronavirus
- ejection fraction
- newly diagnosed
- chronic kidney disease
- atrial fibrillation
- peritoneal dialysis
- machine learning
- left ventricular
- randomized controlled trial
- cardiovascular disease
- high intensity
- early onset
- risk factors
- deep learning
- coronary artery disease
- subarachnoid hemorrhage