The Volatile Oil of Zanthoxylum bungeanum Pericarp Improved the Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota to Attenuate Chronic Unpredictable Stress-Induced Anxiety Behavior in Rats.

Daneng WeiYafei ZhaoMengmeng ZhangLei ZhuLi WangXing YuanChun-Jie Wu

Published in: Drug design, development and therapy (2021)

VOZB showed an ameliorative effect on CUS-induced anxiety behavior, potentially via inhibiting activation of the HPA axis and restoring the dysbiosis of gut microbiota, thus improving the stress-induced abnormality of the microbiota-gut-brain axis.

Keyphrases

stress induced
sleep quality
signaling pathway
white matter
fatty acid
resting state
physical activity
endothelial cells
solid phase extraction