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Genomic Profiling of Rare Undifferentiated Sarcomatoid Subtypes of Pancreatic Carcinomas: In Search of Therapeutic Targets.

Erik B FaberHarris B KrauseKhalid AminPhilip WalkerPeter J HoseinAnthony Frank ShieldsHeinz-Josef LenzAjay PrakashSanjay GoelMatthew J OberleyGiuseppe MalleoClaudio LuchiniJustin H HwangVaia FlorouIgnacio Garrido-LagunaEmil Lou
Published in: JCO precision oncology (2024)
To our knowledge, this work represents the largest molecular analysis of USC tumors to date and showed an increased expression of immune checkpoint genes in USC tumors. These findings provide evidence for further investigation into immune checkpoint inhibitors in USC tumors.
Keyphrases
  • poor prognosis
  • genome wide
  • high grade
  • binding protein
  • dna methylation