Isolation and characterization of HepP: a virulence-related Pseudomonas aeruginosa heparinase.
Nyaradzo DzvovaJane A Colmer-HamoodJohn A GriswoldAbdul Naji HamoodPublished in: BMC microbiology (2017)
Changes within the blood of severely burned patients significantly induced expression of hepP in PA14. The heparinase encoded by hepP is a potential virulence factor for PA14 as HepP influences pellicle formation as well as biofilm development by PA14 and the protein is required for full virulence in the C. elegans model of slow killing.
Keyphrases
- pseudomonas aeruginosa
- biofilm formation
- staphylococcus aureus
- cystic fibrosis
- escherichia coli
- acinetobacter baumannii
- end stage renal disease
- ejection fraction
- antimicrobial resistance
- poor prognosis
- chronic kidney disease
- newly diagnosed
- candida albicans
- prognostic factors
- binding protein
- drug induced
- diabetic rats
- drug resistant
- risk assessment
- multidrug resistant
- long non coding rna
- human health