Discovering Genetic Modulators of the Protein Homeostasis System through Multilevel Analysis.

Vishal Kumar SarsaniBerent AldikactiTingting ZhaoShai HePeter ChienPatrick J Flaherty

Published in: bioRxiv : the preprint server for biology (2024)

, lacks a universal redundancy mechanism for coping with stress, as evidenced by the limited overlap in essential genes across different environmental and genetic perturbations. Our methods also pinpoint key fitness determinants and enable the prediction of perturbation combinations that synergistically affect cell growth.

Keyphrases

genome wide
copy number
depressive symptoms
body composition
dna methylation
physical activity
social support
gene expression
binding protein
protein protein
human health
stress induced