Bone Marrow Mesenchymal Stem Cells Decrease the Expression of RANKL in Collagen-Induced Arthritis Rats via Reducing the Levels of IL-22.

Fang Li Xin Li Guiyan LiuChong GaoXiao-Feng Li

Published in: Journal of immunology research (2019)

Our results suggest that the transplantation of MSCs can reduce the expression of RANKL in vivo by downregulating the levels of IL-22, thereby ameliorating the degree of RA bone destruction. This study provides a theoretical basis for a potential therapy of RA with MSCs, and IL-22 and RANKL may become two new targets to treat RA.

Keyphrases

rheumatoid arthritis
bone loss
poor prognosis
mesenchymal stem cells
disease activity
nuclear factor
ankylosing spondylitis
umbilical cord
bone mineral density
long non coding rna
diabetic rats
cell therapy
oxidative stress
bone marrow
risk assessment
systemic sclerosis
idiopathic pulmonary fibrosis