Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.

Kohei SuzukiTatsuro MuranoHiromichi ShimizuGo ItoToru NakataSatoru FujiiFumiaki IshibashiAmi KawamotoSho AnzaiReiko KunoKonomi KuwabaraJunichi TakahashiMinami HamaSayaka NagataYui HiraguriKento TakenakaShiro YuiKiichiro TsuchiyaTetsuya NakamuraKazuo OhtsukaMamoru WatanabeRyuichi Okamoto

Published in: Journal of gastroenterology (2018)

aCD-SIOs harbor ISCs with modified marker expression profiles, and also with high organoid reformation ability. Results suggest modification of small intestinal stem cell properties by unidentified factors in the inflammatory environment of CD.

Keyphrases

stem cells
disease activity
systemic lupus erythematosus
rheumatoid arthritis
single cell
rheumatoid arthritis patients
ankylosing spondylitis
juvenile idiopathic arthritis
rna seq
cell therapy
oxidative stress
high throughput
nk cells
bone marrow