Bisphenol S favors hepatic steatosis development via an upregulation of liver MCT1 expression and an impairment of the mitochondrial respiratory system.
Bessem MornaguiRaja RezgCendrine RepondLuc PellerinPublished in: Journal of cellular physiology (2022)
Bisphenol S (BPS) is a common substitute of bisphenol A (BPA). Recent data suggest that BPS acts as an obesogenic endocrine disruptor with emerging implications in the physiopathology of metabolic syndrome. However, the effects of BPS on monocarboxylate transporters (acting as carriers for lactate, pyruvate, and ketone bodies) and the mitochondrial respiratory system in the liver remain limited. For this purpose, male Swiss mice were treated with BPS at 100 µg/kg/day for 10 weeks, in drinking water. An increase in body weight and food intake was observed with no increase in locomotor activity. Moreover, data show that BPS increases hepatic MCT1 (a key energetic fuel transporter) mRNA expression accompanied by hepatic steatosis initiation and lipid accumulation, while disrupting mitochondrial function and oxidative stress parameters. Furthermore, BPS produced a significant increase in lactate dehydrogenase and creatine kinase activities. We can suggest that BPS contributes to hepatic steatosis in mice by upregulating monocarboxylate transporters and affecting the bioenergetic status characterized by an impaired mitochondrial respiratory system. Thus, our data highlight a new mechanism putatively implicated in hepatic steatosis development during BPS-induced obesity involving lactate metabolism.
Keyphrases
- oxidative stress
- drinking water
- metabolic syndrome
- body weight
- high fat diet induced
- diabetic rats
- poor prognosis
- electronic health record
- insulin resistance
- big data
- spinal cord injury
- type diabetes
- weight loss
- respiratory tract
- health risk assessment
- risk assessment
- body mass index
- adipose tissue
- ischemia reperfusion injury
- skeletal muscle
- health risk
- induced apoptosis
- high glucose
- cardiovascular risk factors
- physical activity
- artificial intelligence
- wild type