Upregulation of hepatic nuclear receptors in extremely preterm ovine fetuses undergoing artificial placenta therapy.
Hideyuki IkedaShimpei WatanabeShinichi SatoErin L FeeSean W D CarterYusaku KumagaiTsukasa TakahashiShinichi KawamuraTakushi HanitaSebastian Enrique IllanesMahesh Arjandas ChoolaniMasatoshi SaitoAtsuo KikuchiMatthew W KempHaruo UsudaPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2024)
A number of NRs in the fetal liver were significantly upregulated after loss of placental-maternal support. However, the expression of target transporter genes appeared to be insufficient to compensate role of the placenta and maternal liver and avoid fetal liver damage, potentially due to insufficient excretion of organic anions.