STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis.
Junjie ZhaoYun LiaoWilliam Miller-LittleJianxing XiaoCaini LiuXiaoxia LiXiao LiZizhen KangPublished in: Journal of neuroinflammation (2021)
In this study, we identified STEAP4 as a Th17-specific effector molecule that participates and contributes to the pathogenesis of neuroinflammation, thus potentially provide a novel target for MS therapy.
Keyphrases
- induced apoptosis
- poor prognosis
- mass spectrometry
- cell therapy
- single cell
- cell cycle arrest
- traumatic brain injury
- multiple sclerosis
- high glucose
- diabetic rats
- ms ms
- patient safety
- quality improvement
- dendritic cells
- regulatory t cells
- lps induced
- drug induced
- oxidative stress
- blood brain barrier
- cognitive impairment
- signaling pathway
- endoplasmic reticulum stress
- long non coding rna
- cell proliferation
- binding protein
- brain injury