Rhox6 regulates the expression of distinct target genes to mediate mouse PGCLC formation and ESC self-renewal.

Xiaofeng LiPeng ChenJunxiang JiQuanchao DuanJianjian CaoRu HuangShou-Dong Ye

Published in: Cell & bioscience (2023)

Our study reveals that overexpression of Rhox6 is beneficial for PGCLC generation through induction of Nanos3, while downregulation of Rhox6 contributes to mESC self-renewal by increasing Tbx3. These findings help elucidate the early development of mouse embryos.

Keyphrases

cell proliferation
poor prognosis
genome wide
transcription factor
binding protein
long non coding rna
genome wide identification