Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment-The Current State of Knowledge.
Marzena SzwedAgnieszka MarczakPublished in: Cancers (2024)
Hyperthermia (HT) is an anti-cancer therapy commonly used with radio and chemotherapies based on applying heat (39-45 °C) to inhibit tumor growth. However, controlling heat towards tumors and not normal tissues is challenging. Therefore, nanoparticles (NPs) are used in HT to apply heat only to tumor tissues to induce DNA damage and the expression of heat shock proteins, which eventually result in apoptosis. The aim of this review article is to summarize recent advancements in HT with the use of magnetic NPs to locally increase temperature and promote cell death. In addition, the recent development of nanocarriers as NP-based drug delivery systems is discussed. Finally, the efficacy of HT combined with chemotherapy, radiotherapy, gene therapy, photothermal therapy, and immunotherapy is explored.
Keyphrases
- heat stress
- heat shock
- cancer therapy
- cell death
- gene therapy
- dna damage
- oxidative stress
- drug delivery
- gene expression
- cell cycle arrest
- poor prognosis
- locally advanced
- healthcare
- molecularly imprinted
- early stage
- radiation therapy
- dna repair
- binding protein
- oxide nanoparticles
- heat shock protein
- long non coding rna
- drug release
- rectal cancer
- walled carbon nanotubes