Connectomic profiling and Vagus nerve stimulation Outcomes Study (CONNECTiVOS): a prospective observational protocol to identify biomarkers of seizure response in children and youth.
Lauren SiegelHan YanNebras WarsiSimeon WongHrishikesh SureshAlexander G WeilJohn RaghebShelly WangCurtis RozzelleGregory W AlbertJeffrey RaskinTaylor AbelJason HauptmanDewi V SchraderRobert BolloMatthew D SmythSean M LewMelissa LoprestiDominic J KizekHoward L WeinerAria FallahElysa WidjajaGeorge M IbrahimPublished in: BMJ open (2022)
This study was approved by the Hospital for Sick Children Research Ethics Board (REB number 1000061744). All participants, or substitute decision-makers, will provide informed consent prior to be enrolled in the study. Institutional Research Ethics Board approval will be obtained from each additional participating site prior to inclusion. This study is funded through a Canadian Institutes of Health Research grant (PJT-159561) and an investigator-initiated funding grant from LivaNova USA (Houston, TX; FF01803B IIR).