A measles IgM rapid diagnostic test to address challenges with national measles surveillance and response in Malaysia.
A'aisah SeninNoorliza M NoordinJamiatul A M SaniDiana MahatMorgane DonadelHeather M ScobieAziyati OmarYu K ChemMohamad I ZahariFatanah IsmailRozita A RahmanHani M HussinSengol SelvanesanZirwatul A AzizW N Afiza W M ArifinRehan S A BakarNorhayati RusliM Hanif ZailaniPaul SooYing-Ru Jacqueline LoVarja GrabovacPaul A RotaMick N MuldersDavid FeatherstoneLenesha WarrenerDavid W BrownPublished in: PloS one (2024)
The measles IgM RDT shows >95% inter-reader agreement, high retention of RDT knowledge, and a more rapid public health response. However, despite ≥95% RDT specificity using capillary blood or oral fluid, RDT sensitivity was <45%. Higher-powered studies using highly specific IgM assays and systematic RT-qPCR for case confirmation are needed to establish the role of RDT in measles elimination settings.