Symptom Science: Omics and Response to Non-Pharmacological Interventions.
Monica A WagnerSusan W WesmillerMeaghan MaydickLisa M GawronFrances M Peterson-BurchYvette P ConleyPublished in: Biological research for nursing (2020)
Incorporating omics into non-pharmacological intervention research design could provide a better understanding of the variability in response to these interventions. It would also provide evidence for precision-based non-pharmacological interventions, including interventions focused on symptoms. The purpose of this manuscript was to present examples of studies that have used omics to examine response to non-pharmacological intervention. Using the interventions of exercise, diet (related to obesity), cognitive based therapy, and alternative mind-body practices (meditation, yoga, and tai chi), PubMed was searched to identify studies that incorporated genomic or other omic approaches as part of a non-pharmacological intervention. The review identified genes associated with the effectiveness of each of the interventions. Although there were no genes that were associated with all four interventions, there were nine genes that were the focus of more than one intervention (ACE, BDNF, COMT, CXCL8, IL6, SL6A4, TNF, GSTM1, PTGER3). All nine of these genes were either directly or indirectly biologically related to one another, suggesting that this cadre of genes could serve as an initiation point for investigations using omic approaches to better understand response to non-pharmacological interventions.
Keyphrases
- physical activity
- randomized controlled trial
- genome wide
- healthcare
- systematic review
- primary care
- metabolic syndrome
- weight loss
- type diabetes
- rheumatoid arthritis
- public health
- insulin resistance
- dna methylation
- adipose tissue
- body composition
- copy number
- genome wide identification
- skeletal muscle
- angiotensin ii
- sleep quality
- patient reported