Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases.
Lili YuYanhua LiCancan DuWeidong ZhaoHanxiao ZhangYun YangAiping SunXiangfeng SongZhiwei FengPublished in: Mediators of inflammation (2019)
Obesity-induced chronic inflammation is known to promote the development of many metabolic diseases, especially insulin resistance, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and atherosclerosis. Pattern recognition receptor-mediated inflammation is an important determinant for the initiation and progression of these metabolic diseases. Here, we review the major features of the current understanding with respect to obesity-related chronic inflammation in metabolic tissues, focus on Toll-like receptors and nucleotide-binding oligomerization domain-like receptors with an emphasis on how these receptors determine metabolic disease progression, and provide a summary on the development and progress of PRR antagonists for therapeutic intervention.
Keyphrases
- insulin resistance
- oxidative stress
- metabolic syndrome
- type diabetes
- high fat diet induced
- weight loss
- adipose tissue
- randomized controlled trial
- drug induced
- high fat diet
- cardiovascular disease
- skeletal muscle
- polycystic ovary syndrome
- gene expression
- diabetic rats
- glycemic control
- physical activity
- body mass index
- dna binding