Secondary plasma cell leukaemia (PCL) with plasmablastic morphology.
Ke XuElisabeth NachevaPublished in: Journal of hematopathology (2024)
A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology confirmed myeloma with no evidence of acute leukaemia. The patient was diagnosed with plasmablastic progression of myeloma and secondary PCL. Secondary PCL patients have a poor prognosis. It is essential to recognize this subtype and explore a novel treatment approach.
Keyphrases
- bone marrow
- poor prognosis
- newly diagnosed
- multiple myeloma
- induced apoptosis
- flow cytometry
- peripheral blood
- cell cycle arrest
- mesenchymal stem cells
- long non coding rna
- single cell
- cell therapy
- ejection fraction
- end stage renal disease
- acute myeloid leukemia
- acute lymphoblastic leukemia
- signaling pathway
- oxidative stress
- endoplasmic reticulum stress
- stem cells
- room temperature
- genome wide
- cell proliferation
- case report
- patient reported outcomes
- dna methylation
- gold nanoparticles
- pi k akt
- combination therapy
- respiratory failure
- extracorporeal membrane oxygenation