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Fenofibrate Ameliorates Retinal Pigment Epithelium Injury Induced by Excessive Fat Through Upregulation of PI3K/AKT Signaling.
Xue Wang
Xiaomei Liu
Radouil Tzekov
Chaofeng Yu
Jiasong Yang
Yuliang Feng
Ya-Jun Wu
Yali Xu
Shiying Li
Wensheng Li
Published in:
Drug design, development and therapy (2023)
Our results suggested that fenofibrate ameliorated RPE cell damage induced by excessive fat in vitro and in vivo, in part, through activation of the PI3K/AKT signaling pathway.
Keyphrases
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pi k akt
signaling pathway
cell proliferation
adipose tissue
cell cycle arrest
weight gain
epithelial mesenchymal transition
induced apoptosis
single cell
fatty acid
oxidative stress
cell therapy
mouse model
body mass index
bone marrow
mesenchymal stem cells
long non coding rna