Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study.

Guillaume Butler-Laporte Tomoko NakanishiVincent MooserDavid R MorrisonTala AbdullahOlumide AdeleyeNoor MamloukNofar KimchiZaman AfrasiabiNardin RezkAnnarita GilibertiAlessandra RenieriYiheng ChenSirui ZhouVincenzo Forgetta John Brent Richards

Published in: PLoS medicine (2021)

In this 2-sample MR study, we did not observe evidence to support an association between 25OHD levels and COVID-19 susceptibility, severity, or hospitalization. Hence, vitamin D supplementation as a means of protecting against worsened COVID-19 outcomes is not supported by genetic evidence. Other therapeutic or preventative avenues should be given higher priority for COVID-19 randomized controlled trials.

Keyphrases

coronavirus disease
sars cov
randomized controlled trial
respiratory syndrome coronavirus
type diabetes
magnetic resonance
systematic review
magnetic resonance imaging
quality improvement
gene expression
metabolic syndrome
insulin resistance
weight loss
copy number
study protocol