Continuous Thymoquinone Administration Mitigates Sodium Iodate-Induced Retinal Degeneration in Rats.

Pelin Erguven Kubra Sevgin Tuğba Kotil Belisa Kaleci Hifa Gulru Caglar Omer Faruk Ozer

Published in: Current eye research (2024)

The present study provides evidence that continuous TQ treatment can increase HO-1 and RPE65 expression and decrease apoptosis (caspase-3 levels), thereby preserving the retina at the ultrastructural level. Moreover, TQ administration can maintain thiol/disulfide homeostasis in SI-induced retinal degeneration-modelled rats.

Keyphrases

diabetic retinopathy
high glucose
optical coherence tomography
diabetic rats
cell death
optic nerve
oxidative stress
poor prognosis
drug induced
endothelial cells
cell proliferation
long non coding rna
signaling pathway
binding protein
room temperature
pi k akt
replacement therapy
combination therapy