Increased insulin resistance in intensive care: longitudinal retrospective analysis of glycaemic control patients in a New Zealand ICU.
Jennifer L Knopp Nee DicksonJ Geoffrey ChaseGeoffrey M ShawPublished in: Therapeutic advances in endocrinology and metabolism (2021)
Increasing insulin resistance was observed alongside no change in insulin sensitivity variability, implying greater insulin needs but equivalent (variability) challenge to glycaemic control. Increasing insulin resistance may imply greater inflammation and severity of illness not captured by existing severity scores. Insulin resistance reduces glucose tolerance, and can cause greater incidence of insulin saturation and resultant hyperglycaemia. Overall, these results have significant clinical implications for glycaemic control and nutrition management.
Keyphrases
- type diabetes
- insulin resistance
- glycemic control
- high fat diet
- adipose tissue
- polycystic ovary syndrome
- metabolic syndrome
- end stage renal disease
- skeletal muscle
- chronic kidney disease
- high fat diet induced
- oxidative stress
- newly diagnosed
- ejection fraction
- physical activity
- intensive care unit
- risk factors
- patient reported outcomes
- cross sectional
- mechanical ventilation
- weight loss