Neoadjuvant short-course radiotherapy with consolidation chemotherapy for locally advanced rectal cancer: a systematic review and meta-analysis.
Agastya PatelPiotr SpychalskiGiulia CorraoBarbara Alicja Jereczek-FossaRobert Glynne-JonesJulio Garcia-AguilarJarosław KobielaPublished in: Acta oncologica (Stockholm, Sweden) (2021)
This review highlights the ability of SCRT-CCT to produce improved tumor response with comparable OS, R0 resection, and T-downstaging at the cost of increased acute toxicity. However, heterogeneity in treatment protocols across studies makes it difficult to provide definitive conclusions regarding the regimen. Several ongoing trials are expected to provide further evidence confirming the findings of RAPIDO trial and detail appropriate SCRT-CCT protocols to improve oncological outcomes, minimize toxicity, and determine its effectiveness as the standard-of-care for locally advanced rectal cancer patients.
Keyphrases
- rectal cancer
- locally advanced
- oxidative stress
- liver failure
- randomized controlled trial
- healthcare
- clinical trial
- palliative care
- systematic review
- study protocol
- squamous cell carcinoma
- single cell
- respiratory failure
- radiation therapy
- phase ii
- prostate cancer
- quality improvement
- drug induced
- early stage
- case control
- intensive care unit
- affordable care act
- combination therapy