Acetazolamide reduces exercise capacity following a 5-day ascent to 4559 m in a randomised study.

Arthur R BradwellKimberley AshdownCarla RueJohn DelamereOwen D ThomasSamuel J E LucasAlex D WrightStephen J HarrisStephen D Myersnull null

Published in: BMJ open sport & exercise medicine (2018)

Maximum exercise performance at altitude was reduced more in subjects taking Az compared with placebo, particularly in older individuals. The age-related effect may reflect higher tissue concentrations of Az due to reduced renal excretion. Future studies should explore the effectiveness of smaller Az doses (eg, 250 mg daily or less) in older individuals to optimise the altitude-Az-exercise relationships.

Keyphrases

physical activity
high intensity
resistance training
clinical trial
community dwelling
randomized controlled trial
middle aged
open label
current status
phase iii