Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis.
Shadi YaghiIan J SaldanhaChelsea MisquithBashar ZaidatAsghar ShahKareem JoudiBianca PersaudFeras Abdul KhalekLiqi ShuAdam H de HavenonEva A MistryEkaterina BakradzeEric D GoldsteinJohn L ReaganAikaterini TheodorouLina PalaiodimouKaren L FurieThalia Shoshana FieldGeorgios K TsivgoulisBrian Mac GroryPublished in: Stroke (2022)
This systematic review and meta-analysis suggest that in patients with cerebral venous thrombosis, DOACs, and warfarin may have comparable efficacy and safety. Given the limitations of the studies included (low number of randomized controlled trials, modest total sample size, rare outcome events), our findings should be interpreted with caution pending confirmation by ongoing randomized controlled trials and large, prospective, observational studies.