Malaria infection promotes a selective expression of kinin receptors in murine liver.

Priscilla D S VenturaCarolina P F CarvalhoNilana M T BarrosLeonardo Martins-SilvaEdilson O DantasCarolina MartinezPollyana M S MeloJoão B PesqueroAdriana K CarmonaMarcia R NagaokaMarcos Leoni Gazarini

Published in: Malaria journal (2019)

Thus, it was observed through in vivo studies that the vasodilation induced by plasma ACE inhibition increases mice mortality during P. chabaudi infection. Besides, it was also seen that the anti-malarial chloroquine causes changes in B1R expression in liver, even after days of parasite clearance. The differential expression of B1R and B2R in liver during malaria infection may have an important role in the disease pathophysiology and represents an issue for clinical treatments.

Keyphrases

plasmodium falciparum
poor prognosis
binding protein
metabolic syndrome
skeletal muscle
angiotensin converting enzyme