Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer.

Luigi IppolitoGiuseppina ComitoMatteo ParriMarta IozzoAssia DuattiFrancesco Di Virgilio Nicla Lorito Marina Bacci Elisa Pardella Giada Sandrini Francesca BianchiniRoberta DamianoLavinia Ferrone Giancarlo la MarcaSergio SerniPietro Spatafora Carlo Vittorio Catapano Andrea Morandi Elisa GiannoniPaola Chiarugi

Published in: Cancer research (2022)

This work shows that stromal-derived lactate induces accumulation of lipid droplets, stimulates epigenetic rewiring, and fosters metastatic potential in prostate cancer.

Keyphrases

prostate cancer
radical prostatectomy
dna methylation
gene expression
squamous cell carcinoma
small cell lung cancer
fatty acid
bone marrow
human health
risk assessment