Engineered circular guide RNAs boost CRISPR/Cas12a- and CRISPR/Cas13d-based DNA and RNA editing.
Xin ZhangXinlong WangJie LvHongxin HuangJiahong WangMa ZhuoZhihong TanGuanjie HuangJiawei LiuYuchen LiuMengrao LiQixiao LinLian LiShufeng MaTao HuangYing LinXiao-Yang ZhaoZhili RongPublished in: Genome biology (2023)
CgRNAs enable more efficient programmable DNA and RNA editing for Cas12a and Cas13d with broad applicability for fundamental research and gene therapy.