Effect of oral naloxone on opioid-induced constipation in methadone maintenance treatment patients, a double-blind, placebo-control, clinical trial.

Shaghayegh Akhgarandouz Mohammad Moshiri Leila Etemad Bita Dadpour Majid Khadem Rezaiyan Nasser Vahdati-Mashhadian

Published in: Irish journal of medical science (2024)

Oral naloxone at doses of 0.5 and 2 mg/day was significantly more effective than placebo on OIC in MMT. However, the dose of 4 mg induced intolerable OWS.

Keyphrases

clinical trial
high glucose
end stage renal disease
double blind
chronic kidney disease
newly diagnosed
ejection fraction
phase iii
drug induced
chronic pain
prognostic factors
randomized controlled trial
pain management
endothelial cells
open label
study protocol