The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model.

Patricia Molina PratsFrancisco Gómez GarciaFrancisco Martinez DiazRui Amaral MendesPia Lopez-Jornet

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2016)

Apigenin treatment may enhance healing of OM induced by 5-fluorouracil, thus suggesting that more extensive research in this area may be useful to assess the role of agents of natural origin capable of preventing OM. Hence, further studies involving broader samples are need to confirm the therapeutic potential shown by this study.

Keyphrases

high glucose
low dose
high dose
randomized controlled trial
drug induced
oxidative stress
radiation therapy
endothelial cells
replacement therapy
chemotherapy induced