A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment.
Roberto SpreaficoMaura RossettiJorg van LoosdregtCarol A WallaceMargherita MassaSilvia Magni-ManzoniMarco GattornoAlberto MartiniDaniel J LovellSalvatore AlbaniPublished in: Annals of the rheumatic diseases (2014)
CPLs provide an accessible reservoir of pathogenic cells recirculating into the bloodstream and correlating with disease activity, to be exploited for diagnostic and research purposes.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- induced apoptosis
- ankylosing spondylitis
- juvenile idiopathic arthritis
- cell cycle arrest
- water quality
- genome wide
- endoplasmic reticulum stress
- gram negative
- escherichia coli
- signaling pathway
- dna methylation
- oxidative stress
- multidrug resistant