Temporizing management vs immediate delivery in early-onset severe preeclampsia between 28 and 34 weeks of gestation (TOTEM study): An open-label randomized controlled trial.

Johannes J Duvekot Ruben G DuijnhovenEva van HorenCaroline J BaxKitty W M BloemenkampIngrid A BrusséPeter H DijkMaureen T FranssenArie FranxMartijn A OudijkMartina M PorathHubertina C ScheepersAleid G van Wassenaer-LeemhuisJoris van DrongelenBen-Willem J Mol Wessel J Ganzevoortnull null

Published in: Acta obstetricia et gynecologica Scandinavica (2020)

Early termination of the trial precluded any conclusions for the main outcomes. We observed that temporizing management resulted in a modest prolongation of pregnancy without changes in perinatal and maternal outcome. Conducting a randomized study for this important research question did not prove feasible.

Keyphrases

early onset
late onset
randomized controlled trial
study protocol
pregnancy outcomes
pregnant women
gestational age
clinical trial
birth weight
type diabetes
preterm birth
phase iii
metabolic syndrome
adipose tissue
skeletal muscle
physical activity