Dysbiosis and Prematurity: Is There a Role for Probiotics?
Maria Elisabetta BaldassarreAntonio Di MauroManuela CapozzaValentina RizzoFederico SchettiniRaffaella PanzaNicola LaforgiaPublished in: Nutrients (2019)
Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.
Keyphrases
- preterm birth
- low birth weight
- gestational age
- birth weight
- clinical trial
- preterm infants
- healthcare
- systematic review
- public health
- meta analyses
- randomized controlled trial
- pregnant women
- risk assessment
- physical activity
- social media
- pregnancy outcomes
- climate change
- open label
- bacillus subtilis
- phase ii
- human health