Determinants and protective associations of the lupus low disease activity state in a prospective Chinese cohort.
Yanjie HaoShereen OonLanlan JiDai GaoYong FanYan GengXiaohui ZhangGuangtao LiEric F MorandMandana NikpourZhuoLi ZhangPublished in: Clinical rheumatology (2021)
• Low disease activity status (LLDAS) is an achievable target during SLE treatment in China. Urine protein, serum creatinine, and C3 level at recruitment independently affect LLDAS achievement in this group of Chinese lupus patients. • As a treatment target, LLDAS achievement has a highly protective effect for preventing flare and damage accrual, especially in case of achieving LLDAS for ≥ 50% of observations. • The present results further highlight the practical significance of treat-to-target principle in SLE management (T2T/SLE) and the needs for promoting the application of T2T/SLE in clinical practice as well as exploring the concrete implement strategy.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- clinical practice
- end stage renal disease
- newly diagnosed
- oxidative stress
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- combination therapy
- smoking cessation
- small molecule
- uric acid
- binding protein