Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: a link between vascular involvement and fibrosis.

Paola CiprianiPaola Di BenedettoDaria CapeceFrancesca ZazzeroniVasiliki LiakouliPiero RuscittiIlenia PantanoOnorina BerardicurtiFrancesco CarubbiEdoardo AlesseRoberto Giacomelli

Published in: Fibrogenesis & tissue repair (2014)

During SSc, the lower levels of Cav-1 may contribute to the pathogenesis of fibrosis via an upregulation of the VEGF signaling in perivascular cells which are shifted to a profibrotic phenotype.

Keyphrases

induced apoptosis
cell cycle arrest
poor prognosis
vascular endothelial growth factor
endothelial cells
stem cells
bone marrow
cell proliferation
oxidative stress