Injectable Hydrogels Including Magnetic Nanosheets for Multidisciplinary Treatment of Hepatocellular Carcinoma via Magnetic Hyperthermia.
Jinyu GongJinlong HuXu YanLuyao XiangSheng ChenHuai YangZichao ChenQingbing HouYonghong SongYunjun XuDongquan LiuChaofei JiQin QinHaiyi SunJunbin PengBaoqiang CaoYang LuPublished in: Small (Weinheim an der Bergstrasse, Germany) (2023)
Relapse and unresectability have become the main obstacle for further improving hepatocellular carcinoma (HCC) treatment effect. Currently, single therapy for HCC in clinical practice is limited by postoperative recurrence, intraoperative blood loss and poor patient outcomes. Multidisciplinary therapy has been recognized as the key to improving the long-term survival rate for HCC. However, the clinical application of HCC synthetic therapy is restricted by single functional biomaterials. In this study, a magnetic nanocomposite hydrogel (CG-IM) with iron oxide nanoparticle-loaded mica nanosheets (Iron oxide nanoparticles@Mica, IM) is reported. This biocompatible magnetic hydrogel integrated high injectability, magnetocaloric property, mechanical robustness, wet adhesion, and hemostasis, leading to efficient HCC multidisciplinary therapies including postoperative tumor margin treatment and percutaneous locoregional ablation. After minimally invasive hepatectomy of HCC, the CG-IM hydrogel can facilely seal the bleeding hepatic margin, followed by magnetic hyperthermia ablation to effectively prevent recurrence. In addition, CG-IM hydrogel can inhibit unresectable HCC by magnetic hyperthermia through the percutaneous intervention under ultrasound guidance.
Keyphrases
- drug delivery
- minimally invasive
- molecularly imprinted
- hyaluronic acid
- tissue engineering
- wound healing
- clinical practice
- randomized controlled trial
- patients undergoing
- radiofrequency ablation
- free survival
- quantum dots
- escherichia coli
- drug release
- quality improvement
- computed tomography
- cystic fibrosis
- mass spectrometry
- highly efficient
- pseudomonas aeruginosa
- bone marrow
- cell migration