Seizure Cycles under Pharmacotherapy.
Cecilia L Friedrichs-MaederTimothée ProixThomas K TchengTara SkarpaasVikram R RaoMaxime O BaudPublished in: Annals of neurology (2024)
In this large cohort, a decrease in multidien IEA cycle strength following initiation of an adjunctive ASM correlated with seizure control for up to 12 months, suggesting that fluctuations in IEA mirror "disease activity" in pharmacoresistant focal epilepsy and may have clinical utility as a biomarker to predict treatment response. ANN NEUROL 2024.