Novel Salinomycin-Based Paramagnetic Complexes-First Evaluation of Their Potential Theranostic Properties.
Irena Pashkunova-MarticRositsa KukevaRadostina K StoyanovaIvayla PantchevaPetar DorkovJoachim FriskeMichaela HejlMichael A JakupecMariam HohagenAnton A LeginWerner LubitzBernhard K KepplerThomas H HelbichJuliana IvanovaPublished in: Pharmaceutics (2022)
This research is the first assessment that demonstrates the potential of Gd(III) and Mn(II) complexes of Sal as theranostic agents for MRI. Due to the remarkable selectivity and mode of action of Sal as part of the compounds, they could revolutionize cancer therapy and allow for early diagnosis and monitoring of therapeutic follow-up.