Inflammatory Gene Expression Profile and Defective Interferon-γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients.

Karen PutJessica VandenhauteAnneleen AvauAnnemarie van NieuwenhuijzeEllen BrisseTim DierckxOmer RutgeertsJosselyn E Garcia-PerezJaan ToelenMark WaerGeorges LeclercqAn GorisJohan Van WeyenberghAdrian ListonLien De SomerCarine H WoutersPatrick Matthys

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2017)

NK cells are active players in the inflammatory environment typical of systemic JIA. Although their cytotoxic function is globally intact, subtle defects in NK-related pathways, such as granzyme K expression and IL-18-driven IFNγ production, may contribute to the immunoinflammatory dysregulation in this disease.

Keyphrases

juvenile idiopathic arthritis
nk cells
gene expression
end stage renal disease
dendritic cells
newly diagnosed
ejection fraction
poor prognosis
chronic kidney disease
immune response
prognostic factors
disease activity
peritoneal dialysis
binding protein
systemic lupus erythematosus