A lymphodepleted non-human primate model for the assessment of acute on-target and off-tumor toxicity of human chimeric antigen receptor-T cells.

Shigeki YagyuHidemi MochizukiKumiko YamashimaHiroshi KuboShoji Saito Miyuki TanakaKengo SakamotoAkihito ShimoiYozo Nakazawa

Published in: Clinical & translational immunology (2021)

Although this NHP model is limited for the full evaluation of toxicity of human CAR-T cells and the conditioning protocol should be further optimised, this lymphodepleted NHP model could be used to assess acute on-target/off-tumor toxicities of CAR-T cells.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
respiratory failure
drug induced