Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis.
Abdullah R AlzahraniDoaa I MohamedHebatallah H Abo NahasDalia Alaa El-Din Aly El-WaseefAbdulmalik S AltamimiIbrahim H YoussefIbrahim Abdel Aziz IbrahimSoha M Y MohamedYasmine Gamal SabryAlaa Hisham FalembanNasser Attia ElhawaryGhazi A BamagousMariusz JaremkoEssa M SaiedPublished in: Drug design, development and therapy (2024)
Taken together, our study showed for the first time the interplay between epigenetic lncRNAs CBR3-AS1 and miRNA-29 in lung fibrosis and demonstrated that FIZZ1 could be a downregulatory gene for lncRNA CBR3-AS1 and miRNA-29. Our key findings demonstrate that TMZ significantly reduces the expression of fibrotic, oxidative stress, immunomodulatory, and inflammatory markers, along with epigenetic regulators associated with lung fibrosis. This validates its potential as an effective antifibrotic agent by targeting the CBR3-AS1/miRNA-29/FIZZ1 axis.
Keyphrases
- long noncoding rna
- pulmonary fibrosis
- oxidative stress
- dna methylation
- gene expression
- poor prognosis
- long non coding rna
- diabetic rats
- transcription factor
- genome wide
- high glucose
- copy number
- idiopathic pulmonary fibrosis
- induced apoptosis
- signaling pathway
- endothelial cells
- binding protein
- endoplasmic reticulum stress
- stress induced
- genome wide analysis