Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies.
Tim D FryerSohail EjazUlf Jensen-KonderingDavid J WilliamsonSergey SitnikovStephen J SawiakFranklin I AigbirhioYoung T HongJean Claude BaronPublished in: PloS one (2017)
Despite small samples, the apparent lack of marked effects of NBO on FMISO uptake suggests that in permanent ischemia the cellular mechanisms underlying FMISO trapping in hypoxic cells may be disjointed from PtO2. Better understanding of FMISO trapping processes will be important for future applications of FMISO imaging.
Keyphrases
- middle cerebral artery
- induced apoptosis
- internal carotid artery
- high resolution
- cell cycle arrest
- positron emission tomography
- white matter
- current status
- magnetic resonance imaging
- cell death
- study protocol
- clinical trial
- randomized controlled trial
- endoplasmic reticulum stress
- multiple sclerosis
- cell proliferation
- photodynamic therapy
- diffusion weighted imaging
- pi k akt
- brain injury