Skeletal muscle characteristics are preserved in hTERT/cdk4 human myogenic cell lines.

Matthew ThorleyStéphanie DuguezEmilia Maria Cristina MazzaSara ValsoniAnne BigotKamel MamchaouiBrennan HarmonThomas VoitVincent MoulyWilliam John Duddy

Published in: Skeletal muscle (2016)

Immortalization had no observed effect on the myogenic cascade or on any other cellular processes, and it was protective against the systems level effects of senescence that are observed at higher division counts of primary cells.

Keyphrases

skeletal muscle
endothelial cells
induced apoptosis
insulin resistance
cell cycle arrest
cell cycle
dna damage
induced pluripotent stem cells
pluripotent stem cells
oxidative stress
signaling pathway
endoplasmic reticulum stress
metabolic syndrome
adipose tissue
cell proliferation
stress induced
pi k akt