Multimodal platform for assessing drug distribution and response in clinical trials.
Begoña G C LopezIshwar N KohaleZiming DuIlya KorsunskyWalid M AbdelmoulaYang DaiSylwia A StopkaGiorgio GagliaElizabeth C RandallMichael S ReganSankha S BasuAmanda R ClarkBianca-Maria MarinAnn C MladekDanielle M BurgenskeJeffrey N AgarJeffrey G SupkoStuart A GrossmanLouis B NaborsSoumya RaychaudhuriKeith L LigonPatrick Y WenBrian AlexanderEudocia Q LeeSandro SantagataJann SarkariaForest M WhiteNathalie Y R AgarPublished in: Neuro-oncology (2021)
The multimodal platform identified a signature of drug efficacy and patient-specific adaptive responses applicable to pre-clinical and clinical drug development. The information generated by the approach may inform mechanisms of success and failure in future early phase clinical trials, providing information for optimizing clinical trial design and guiding future application into clinical practice.