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Expression Biomarkers of Pharmacological Treatment Outcomes in Women with Unipolar and Bipolar Depression.

Monika Dmitrzak-WęglarzAleksandra SzczepankiewiczJanusz K RybakowskiPaweł KapelskiKarolina BilskaMaria SkibińskaEdyta ReszkaMonika LesickaEwa JabłońskaEdyta WieczorekJoanna M Pawlak
Published in: Pharmacopsychiatry (2021)
Based on transcriptomic profiling, we identified potential expression biomarkers of treatment outcomes for UD and BD. We also proved that the Ras-GEF pathway associated with long-term memory, female stress response, and treatment response modulation in animal studies impacts treatment efficacy in patients with BD. Further studies focused on the outlined genes may help provide predictive markers of treatment outcomes in UD and BD.
Keyphrases
  • poor prognosis
  • single cell
  • depressive symptoms
  • bipolar disorder
  • long non coding rna
  • rna seq
  • gene expression
  • sleep quality
  • physical activity
  • climate change
  • human health