Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression.

Leonid Kharin Igor BychkovNikolay KarnaukhovMark VoloshinRushaniya FazliyevaAlexander DenekaElena FrantsiyantsOleg KitErica GolemisYanis Boumber

Published in: PloS one (2021)

Elevated expression of MSI2 is associated with pre-cancerous TAs in the colonic mucosa, suggesting it is an early event in transformation. MSI2 expression is further elevated during CRC progression, and associated with poor prognosis. Depletion of MSI2 reduces CRC cell growth. These data imply a causative role of MSI2 overexpression at multiple stages of CRC formation and progression.

Keyphrases

poor prognosis
long non coding rna
rheumatoid arthritis
cell proliferation
electronic health record
machine learning
transcription factor
artificial intelligence