Aspirin delays the onset of hypertensive disorders of pregnancy among nulliparous pregnant women: A secondary analysis of the ASPIRIN trial.
Avinash KaviMatthew K HoffmanManjunath S SomannavarMrityunjay C MetgudShivaprasad S GoudarJanet MooreEleanor NielsenNorman GocoElizabeth M McClureAdrien LokangakaAntoinette TshefuMelissa BausermanMusaku MwenechanyaElwyn ChombaWaldemar A CarloLester FigueroaNancy F KrebsSaleem JessaniSarah SaleemRobert L GoldenbergPrabirkumar DasArchana B PatelPatricia L HibberdFabian EsamaiSherri BucherMarion Koso-ThomasRobert SilverRichard J DermanPublished in: BJOG : an international journal of obstetrics and gynaecology (2023)
In this secondary analysis of a study of low-risk nulliparous singleton pregnancies, early administration of LDA resulted in lower rates of preterm HDP and delivery before 34 and 37 weeks but not in the overall rate of HDP. These results suggest that LDA works in part by delaying HDP.
Keyphrases
- preterm birth
- gestational age
- pregnant women
- low dose
- birth weight
- low birth weight
- pregnancy outcomes
- cardiovascular events
- antiplatelet therapy
- blood pressure
- study protocol
- clinical trial
- phase iii
- type diabetes
- anti inflammatory drugs
- phase ii
- randomized controlled trial
- acute coronary syndrome
- coronary artery disease